27 RESULTS
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COMMENT The news story about fabrication of results by Sylvain Lesné is both disturbing and sad. Above all else, science should be about the pursuit of truth. While it is excusable to misinterpret results, it is totally unacceptable to falsify data. A basic tenet
COMMENT This report builds on compelling data from multiple laboratories demonstrating that PrP preferentially binds to soluble Aβ aggregates, weakly interacts with Aβ fibrils, and shows little affinity for Aβ monomers (reviewed in Corbett et al., 2020). The curr
COMMENT David Allsop was a man of several important firsts and was widely respected for his many contributions to AD research. In the early 1980s, David worked at the University of Nottingham, where, with Michael Kidd, the discoverer of neurofibrillary tangles, h
COMMENT This is an interesting study that reports on an experimental platform to explore the cellular mechanisms of prion toxicity. Prions are ordered aggregates of the cellular prion protein (PrPc) that provide a template on which PrPc monomer is thought to bind
COMMENT I think this paper is interesting for several reasons, not least of which is the fact that it appears to reproduce an earlier finding of increased amyloid in a recipient of a dura transplant. Also, it is telling that again there is no detectable tau patho
COMMENT be associated with the development of Aβ deposits. Some specific comments: 1. This paper does not
COMMENT This is a very nice study that brings together the use of several different approaches—mathematical modeling of protein polymerization, reliable assay systems to measure kinetics of Aβ aggregation, and innovative use of radiolabeled Aβ and size-exclusion
COMMENT This is an interesting study that addresses two important issues relating to the role of Aβ in memory impairment, namely biophysical characterization of synthetic memory-impairing assemblies and the requirement of PrPc for memory impairment. Using atomic
COMMENT Homing In on the Molecular Determinants of Aβ Assembly and Toxicity: Lessons from the Computer, Test Tube, and Fly The paper by Luheshi et al. describes the direct comparison of in silico, in vitro, and in vivo analysis of Aβ aggregation. It builds on man
COMMENT Aβ Takes a Turn for the Better? Using a powerful combination of biochemistry, biophysics, and mathematics, Grant and colleagues build on their earlier observation that wild-type Aβ1-40 and 1-42 contain a stretch of 10 amino acids (spanning residues 21-30)
COMMENT This is an extensive and very carefully controlled study in which the authors demonstrate that cathepsin B (CatB) can readily degrade Aβ in vivo and in vitro. At pH 6.0, CatB similarly degrades both non-aggregated and aggregated synthetic Aβ1-42, while at
COMMENT This study is impressive both for the breadth and detail of the experiments undertaken. Using the well-characterized Tg2576 APP transgenic mouse line, the authors searched for the appearance of an Aβ species that coincided with the first observed changes
COMMENT An interesting study that suggests a link between Abeta oligomers, GSK-3beta and tau hyperphosphorylation. 0 dwalsh3
COMMENT An excellent overview of the pathology of an understudied AD-related disease. 0 dwalsh3
COMMENT So long forgotten, interest in the APLPs is slowly growing. This paper clearly demonstrates that overexpression of APLP1 leads to a dramatic change in APP processing, causing a decrease in β processing and an increase in α-processing. Although many questi
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